Important Safety Information
Jump to a treatment
- Compounded Semaglutide
- Semaglutide Microdose
- Compounded Tirzepatide
- Tirzepatide Microdose
- NAD+
- Sermorelin
Emergency & Adverse Events
If you think you are experiencing a medical emergency, call 911 or go to the nearest emergency room.
If you experience side effects or have concerns, contact your prescribing clinician and/or dispensing pharmacy. You may also report suspected adverse reactions to the FDA's MedWatch program at 1-800-FDA-1088 or fda.gov/medwatch.
About Rewinding Services
Rewinding RX provides software and administrative services that facilitate access to consultations with licensed clinicians. Prescriptions are issued only when a licensed clinician determines they are medically appropriate. Rewinding RX is not a pharmacy and does not manufacture medications; fulfillment is handled by third-party pharmacies where permitted.
Compounded medications are prepared by a licensed pharmacy based on a clinician's prescription. Compounded drugs are not FDA-approved and may differ from commercially available FDA-approved products in appearance, concentration, inactive ingredients, or dosing form.
Treatment-Specific Safety Information
Compounded Semaglutide (GLP-1)
Intended use (general)
Compounded semaglutide is prescribed by a licensed clinician for eligible adults when medically appropriate. It may support appetite regulation and metabolic signaling.
Do not use if:
- You have a personal or family history of medullary thyroid carcinoma (MTC), or you have Multiple Endocrine Neoplasia syndrome type 2 (MEN2).
Key warnings & precautions (not complete)
Semaglutide carries a boxed warning related to the risk of thyroid C-cell tumors in rodents; relevance to humans is unknown.
Other important risks discussed in FDA labeling for semaglutide products include:
- Pancreatitis (stop and seek medical evaluation if severe abdominal pain occurs)
- Gallbladder problems, kidney problems (particularly if dehydration occurs), and hypoglycemia risk when used with certain diabetes medications (as applicable)
- Allergic reactions (seek urgent care for swelling, trouble breathing, hives)
Common side effects (examples)
Many patients experience gastrointestinal effects such as nausea, vomiting, diarrhea, constipation, or stomach discomfort often dose-dependent.
Drug interactions / other considerations
Tell your clinician about all medications and supplements you take. GLP-1 therapies may slow gastric emptying and can affect the absorption of some oral medications.
Pregnancy & breastfeeding
Inform your clinician if you are pregnant, planning pregnancy, or breastfeeding.
Semaglutide Microdose
Microdosing typically emphasizes gradual introduction and individualized dosing. Lower doses do not eliminate risk. The same contraindications and warnings apply as for semaglutide therapy generally, including the MTC/MEN2 contraindication and other important risks.
Compounded Tirzepatide (dual GIP/GLP-1)
Intended use (general)
Compounded tirzepatide is prescribed by a licensed clinician for eligible adults when medically appropriate. It may support appetite regulation and metabolic signaling.
Do not use if:
- You have a personal or family history of medullary thyroid carcinoma (MTC), or you have Multiple Endocrine Neoplasia syndrome type 2 (MEN2).
Key warnings & precautions (not complete)
Tirzepatide products include a boxed warning related to the risk of thyroid C-cell tumors in rodents; relevance to humans is unknown.
Other important risks discussed in FDA labeling for tirzepatide products include:
- Pancreatitis (seek evaluation for severe abdominal pain)
- Gallbladder problems, kidney problems (especially with dehydration), and hypoglycemia risk when used with certain diabetes medications (as applicable)
- Allergic reactions
Common side effects (examples)
Gastrointestinal side effects can occur (nausea, vomiting, diarrhea, constipation), often dose-dependent.
Drug interactions / other considerations
Tell your clinician about all medications and supplements you take. As with GLP-1 therapies, slowed gastric emptying may affect the absorption of some oral medications.
Pregnancy & breastfeeding
Inform your clinician if you are pregnant, planning pregnancy, or breastfeeding.
Tirzepatide Microdose
Microdosing typically emphasizes gradual introduction and individualized dosing. Lower doses do not eliminate risk. The same contraindications and warnings apply as for tirzepatide therapy generally, including the MTC/MEN2 contraindication and other important risks.
NAD+
Intended use (general)
NAD+ may be prescribed by a licensed clinician when medically appropriate. NAD+ is sometimes used in clinician-guided wellness/longevity protocols.
Important considerations
- NAD+ products may be compounded depending on formulation and route. Compounded products are not FDA-approved.
- Side effects can vary by individual and route of administration; some people may experience temporary symptoms such as flushing/warmth, nausea, headache, or injection-site reactions.
Who should be cautious?
Tell your clinician if you have cardiovascular conditions, are pregnant or breastfeeding, or take prescription medications - so your clinician can assess whether NAD+ is appropriate for you.
Sermorelin
Intended use (general)
Sermorelin may be prescribed by a licensed clinician when medically appropriate. Historically, sermorelin acetate (Geref) was FDA-approved for specific pediatric use and later discontinued for commercial reasons; compounded sermorelin is used in some settings at the clinician's discretion.
Important considerations
- When used today, sermorelin is often provided via compounding pharmacies; compounded products are not FDA-approved.
- Potential side effects can include injection-site reactions and other effects depending on patient factors and dosing.
Who should be cautious?
Tell your clinician about any history of cancer, endocrine disorders, pregnancy/breastfeeding, or medications - so they can assess appropriateness and monitoring needs.
Final notes
This page is provided for educational purposes and does not replace medical advice. Treatment is prescribed only after review by a licensed clinician, and individual risks vary.